NEW Covid variants are up to eight times more infectious than the original strain found in Wuhan, a study has found.
A mutation dubbed D614G is one of the most dominant mutations globally – and is responsible for making new variants far more infectious, experts say.
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A mutant strain of Covid has made the virus eight times more infectiousCredit: Alamy Live News
Th D614G variant is now one of the most dominant mutations of Covid in the worldCredit: Getty Images – Getty
Since the SARS-Cov-2 virus first emerged it has mutated countless times.
Scientists across the world have worked tirelessly to find out if new variants of the virus are more deadly, and if they can resist vaccines.
Now, a new study published in the journal eLife found the D614G mutation, which is present in the South African, Brazilian and Kent Covid variants, makes the virus more transmissible.
It is one of many mutations that targets the spike protein – the protein which binds with human cells and allows the virus to infect.
Researchers in the US found the D614G mutation likely emerged in early 2020.
It is now one of the most prevalent and dominant mutations in variants that have been detected across the world.
A team made up of researchers from at New York University, the New York Genome Center, and Mount Sinai, introduced a strain of the virus with the D614G mutation to human lung, liver, and colon cells.
To compare, they also conducted the same research with a version of a virus without the mutation found early on in the pandemic into the same cell types.
The scientists found that the variant carrying the D614G mutation increased transmissibility of Covid by up to eight times in comparison to the original virus.
Dr Neville Sanjana, one of the researchers of the study said it may explain why the virus has spread so fast.
“In the months since we initially conducted this study, the importance of the D614G mutation has grown: the mutation has reached near universal prevalence and is included in all current variants of concern,” he said.
“Confirming that the mutation leads to more transmissibility may help explain, in part, why the virus has spread so rapidly over the past year.”
The D614G spike mutation is not, however, linked to a more severe form of Covid.
Zharko Daniloski, a postdoctoral fellow in Sanjana’s lab at NYU and the New York Genome Center and the study’s co-first author, said: “Going into this project we didn’t really know if D614G mutation would have any functional effects, as its wide spread could be due to a founder effect, where a variant becomes dominant because a small number of individuals spread it widely by chance.
“However, our experimental data was pretty unambiguous – the D614G variant infects human cells much more efficiently than the wild type.”
It comes after scientists fear the UK and California Covid variants have merged to create a new hybrid mutation.
The apparent discovery in a US virus sample has sparked concerns the pandemic could enter a new phase.
The “recombination” was discovered in California’s Los Alamos National Laboratory, New Scientist reports.
It’s not yet known how much of a threat the recombination could pose.
But if confirmed the recombinant would be the first detected in the pandemic.
The reocmbinant carries a mutation from the Kent variant – known as B.1.1.7 – which makes the UK virus more transmissible.
It also carries another mutation from the California variant – known as B.1.429 – that can produce resistance to antibodies.
The Kent Covid variant has swiftly become the most dominant in parts of the UK, having emerged only a few months ago.
It’s up to 70 per cent more infectious than than the original strain, scientists fear.
Meanwhile, the South African Covid variant could reduce the protection offered by the Pfizer vaccine, experts have warned.
A new study suggests the strain may make the jab two thirds less effective.
Pfizer/BionTech revealed the study’s findings on Wednesday and said it is not yet known if their Covid jab will work against the fast-spreading mutation.
In South Africa, the B.1.351 Covid variant emerged independently of the UK Kent strain, known as B.1.1.7.
The South African strain has been found to spread about 60-70 per cent faster than the original strain.
According to the study, published by the New England Journal of Medicine (NEJM), the virus can be neutralized by the vaccine.
However, the companies said no evidence exists that the variant reduces vaccine protection.